Abstract: Diabetic retinopathy (DR) is one of the common microvascular complications of diabetes. Previous studies have highlighted the association of chronic inflammation and DR. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) have been proven to be potential inflammatory markers in diabetes mellitus and DR. All the makers above are derived from blood routine test, which is economical, practical, convenient and quick, and have a good application prospect. However, due to the influence of systemic conditions, drug use and other factors, it is currently not widely used in the clinic. Strengthening the monitoring of these makers is helpful for the diagnosis and prognosis of DR. (Int Rev Ophthalmol, 2023, 47: 345-349)

Key words: diabetic retinopathy, inflammation, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammation index